| CAMPEONATO DE APERTURA 2023 | ||||
| 1º Fecha | ||||
| 27-ene-2023 | Asuncion | Libertad | 1 | Villaba (P) |
| Guarani | 0 | |||
| 28-ene-2023 | Asuncion | Sportivo Trinidense | 2 | Barrios (P), Roman |
| Tacuary | 0 | |||
| 28-ene-2023 | Villarrica | Guaireña | 1 | Viera |
| Nacional | 3 | Ocampos (2), Arrua | ||
| 29-ene-2023 | Doctor Juan | General Caballero | 2 | Romero, Gonzalez |
| Leon Mallorquin | Resistencia | 0 | ||
| 29-ene-2023 | Asuncion | Cerro Porteño | 1 | Aquino |
| Sportivo Ameliano | 1 | Arce | ||
| 30-ene-2023 | Asuncion | Olimpia | 2 | Peralta (A), Cardozo |
| Sportivo Luqueño | 1 | Perez | ||
| 2º Fecha | ||||
| 3-feb-2023 | Asuncion | Tacuary | 1 | Valdez (P) |
| Guaireña | 2 | Lima, Otazu | ||
| 3-feb-2023 | Asuncion | Guarani | 2 | Caceres, Santander (P) |
| Sportivo Ameliano | 2 | Vera, Bareiro | ||
| 4-feb-2023 | Encarnacion | Sportivo Trinidense | 0 | |
| Cerro Porteño | 1 | Morales | ||
| 4-feb-2023 | Asuncion | Resistencia | 0 | |
| Libertad | 2 | Melgarejo (2) | ||
| 5-feb-2023 | Luque | Sportivo Luqueño | 1 | Perez |
| General Caballero | 1 | Ovelar (P) | ||
| 8-mar-2023 | Asuncion | Nacional | 1 | Aguilar |
| Olimpia | 1 | Gonzalez (P) | ||
| 3º Fecha | ||||
| 10-feb-2023 | Asuncion | Sportivo Ameliano | 0 | |
| Resistencia | 3 | Martinez, Salinas, Pereira | ||
| 10-feb-2023 | Asuncion | Libertad | 1 | Oviedo |
| Sportivo Luqueño | 1 | Perez | ||
| 11-feb-2023 | Doctor Juan | General Caballero | 0 | |
| Leon Mallorquin | Nacional | 1 | Candia | |
| 11-feb-2023 | Asuncion | Cerro Porteño | 1 | Churin |
| Guarani | 1 | Caceres | ||
| 12-feb-2023 | Villarrica | Guaireña | 1 | Lima |
| Sportivo Trinidense | 1 | Gimenez | ||
| 12-feb-2023 | Asuncion | Olimpia | 4 | Bruera (P), Gonzalez, Paiva, Montenegro |
| Tacuary | 0 | |||
| 4º Fecha | ||||
| 17-feb-2023 | Asuncion | Resistencia | 0 | |
| Guarani | 4 | Barcelo (2), Camacho, Moya | ||
| 17-feb-2023 | Villarrica | Guaireña | 0 | |
| Cerro Porteño | 2 | Morales, Viera | ||
| 18-feb-2023 | Encarnacion | Sportivo Trinidense | 3 | Delvalle, Gimenez, Riveros |
| Olimpia | 1 | Zabala | ||
| 18-feb-2023 | Asuncion | Nacional | 1 | A. Gomez |
| Libertad | 2 | D. Gomez, Villalba | ||
| 19-feb-2023 | Asuncion | Tacuary | 1 | Ferreira |
| General Caballero | 1 | Ovelar (P) | ||
| 19-feb-2023 | Luque | Sportivo Luqueño | 1 | Ledesma |
| Sportivo Ameliano | 1 | Sarquis | ||
| 5º Fecha | ||||
| 24-feb-2023 | Asuncion | Sportivo Ameliano | 0 | |
| Nacional | 0 | |||
| 24-feb-2023 | Asuncion | Cerro Porteño | 1 | Fernandez |
| Resistencia | 1 | Mazur | ||
| 25-feb-2023 | Asuncion | Guarani | 3 | Barcelo, Camacho (2) |
| Sportivo Luqueño | 1 | Perez | ||
| 25-feb-2023 | Asuncion | Libertad | 1 | Oviedo |
| Tacuary | 0 | |||
| 26-feb-2023 | Doctor Juan | General Caballero | 1 | Hauche |
| Leon Mallorquin | Sportivo Trinidense | 4 | Mana, Romero (A), Riveros, Ayala | |
| 26-feb-2023 | Asuncion | Olimpia | 1 | Silva (P) |
| Guaireña | 1 | Nuñez | ||
| 6º Fecha | ||||
| 2-mar-2023 | Asuncion | Tacuary | 1 | Ruiz |
| Sportivo Ameliano | 3 | Sarquis (2), Caceres | ||
| 3-mar-2023 | Villarrica | Guireña | 0 | |
| General Caballero | 0 | |||
| 3-mar-2023 | Asuncion | Nacional | 0 | |
| Guarani | 2 | Barcelo, Fariña | ||
| 4-mar-2023 | Asuncion | Olimpia | 2 | Silva, Gonzalez (P) |
| Cerro Porteño | 2 | Espinola, Aquino (P) | ||
| 5-mar-2023 | Luque | Sportivo Luqueño | 1 | Charpentier |
| Resistencia | 0 | |||
| 5-mar-2023 | Encarnacion | Sportivo Trinidense | 1 | Jara (P) |
| Libertad | 2 | Melgarejo, Cardozo | ||
| 7º Fecha | ||||
| 11-mar-2023 | Asuncion | Libertad | 2 | Melgarejo, Villalba |
| Guaireña | 0 | |||
| 12-mar-2023 | Doctor Juan | General Caballero | 1 | Gonzalez |
| Leon Mallorquin | Olimpia | 2 | Gonzalez (P), Cardozo | |
| 12-mar-2023 | Asuncion | Resistencia | 0 | |
| Nacional | 1 | Caballero | ||
| 13-mar-2023 | Luque | Sportivo Ameliano | 2 | Ortiz, Torales |
| Sportivo Trinidense | 1 | Mana | ||
| 13-mar-2023 | Asuncion | Cerro Porteño | 3 | Carrascal, Bobadilla, Samudio |
| Sportivo Luqueño | 3 | Perez (P), Charpentier, Aguilar | ||
| 14-mar-2023 | Asuncion | Guarani | 1 | Caceres |
| Tacuary | 0 | |||
| 8º Fecha | ||||
| 18-mar-2023 | Villarrica | Guaireña | 0 | |
| Sportivo Ameliano | 1 | Torales | ||
| 18-mar-2023 | Asuncion | Nacional | 0 | |
| Sportivo Luqueño | 1 | Perez | ||
| 19-mar-2023 | Asuncion | Olimpia | 2 | Montenegro, Bruera |
| Libertad | 1 | Villalba (P) | ||
| 19-mar-2023 | Encarnacion | Sportivo Trinidense | 1 | Delvalle |
| Guarani | 1 | Camacho | ||
| 20-mar-2023 | Doctor Juan | General Caballero | 2 | Sanguina (P), Baez |
| Leon Mallorquin | Cerro Porteño | 3 | Samudio, Churin, Carrizo | |
| 20-mar-2023 | Asuncion | Tacuary | 2 | Ruiz, Valdez |
| Resistencia | 0 | |||
| 9º Fecha | ||||
| 24-mar-2023 | Asuncion | Guarani | 1 | Santander |
| Guaireña | 1 | Cabañas | ||
| 25-mar-2023 | Luque | Sportivo Ameliano | 2 | Sarquis (2) |
| Olimpia | 2 | Montenegro, Paiva | ||
| 25-mar-2023 | Asuncion | Cerro Porteño | 4 | Cardozo Lucena, Carrizo, Aquino, Bobadilla |
| Nacional | 1 | |||
| 26-mar-2023 | Luque | Sportivo Luqueño | 2 | Ruiz Diaz, Duarte |
| Tacuary | 0 | |||
| 26-mar-2023 | Asuncion | Resistencia | 1 | Nuñez |
| Sportivo Trindense | 0 | |||
| 30-mar-2023 | Asuncion | Libertad | 1 | Ramirez |
| General Caballero | 0 | |||
| 10º Fecha | ||||
| 31-mar-2023 | Asuncion | Tacuary | 0 | |
| Nacional | 0 | |||
| 31-mar-2023 | Asuncion | Olimpia | 0 | |
| Guarani | 1 | Caceres | ||
| 1-abr-2023 | Encarnacion | Sportivo Trinidense | 2 | Delvalle, Jara |
| Sportivo Luqueño | 2 | Ruiz Diaz, Perez | ||
| 1-abr-2023 | Villarrica | Guaireña | 1 | Valdez |
| Resistencia | 3 | Pereira, Sombra, Duarte | ||
| 2-abr-2023 | Asuncion | Libertad | 5 | Cardozo (4, 1P), Barboza |
| Cerro Porteño | 0 | |||
| 2-abr-2023 | Doctor Juan | General Caballero | 0 | |
| Leon Mallorquin | Sportivo Ameliano | 1 | Vera | |
| 11º Fecha | ||||
| 8-abr-2023 | Asuncion | Nacional | 0 | |
| Sportivo Trinidense | 1 | Alvarez | ||
| 8-abr-2023 | Luque | Sportivo Luqueño | 0 | |
| Guaireña | 0 | |||
| 9-abr-2023 | Asuncion | Resistencia | 0 | |
| Olimpia | 3 | Zarate, Cardozo, Bruera (P) | ||
| 9-abr-2023 | Asuncion | Cerro Porteño | 1 | Churin |
| Tacuary | 0 | |||
| 10-abr-2023 | Luque | Sportivo Ameliano | 2 | Vera (2, 1P) |
| Libertad | 5 | Cardozo (2, 1P), Sanabria, Gomez, Melgarejo | ||
| 10-abr-2023 | Asuncion | Guarani | 3 | Amarilla, Camacho (2, 1P) |
| General Caballero | 1 | Saborido | ||
| 12º Fecha | ||||
| 11-abr-2023 | Asuncion | Nacional | 2 | Aguilar (2) |
| Guaireña | 2 | Nuñez, Verdun | ||
| 12-abr-2023 | Luque | Sportivo Luqueño | 1 | Torres (A) |
| Olimpia | 0 | |||
| 12-abr-2023 | Asuncion | Tacuary | 0 | |
| Sportivo Trinidense | 1 | Alvarez | ||
| 13-abr-2023 | Luque | Sportivo Ameliano | 1 | Bogado (P) |
| Cerro Porteño | 2 | Carrascal, Samudio | ||
| 13-abr-2023 | Asuncion | Guarani | 0 | |
| Libertad | 0 | |||
| 14-abr-2023 | Asuncion | Resistencia | 1 | Da Silva |
| General Caballero | 1 | Sanguina | ||
| 13º Fecha | ||||
| 15-abr-2023 | Villarrica | Guaireña | 0 | |
| Tacuary | 1 | Ayala | ||
| 15-abr-2023 | Asuncion | Olimpia | 0 | |
| Nacional | 1 | Alfaro | ||
| 16-abr-2023 | Asuncion | Cerro Porteño | 3 | Fernandez (2), Galeano |
| Sportivo Trinidense | 2 | Roman, Barrios | ||
| 16-abr-2023 | Luque | Sportivo Ameliano | 1 | Vera |
| Guarani | 1 | Benitez | ||
| 17-abr-2023 | Asuncion | Libertad | 4 | Gonzalez, Cardozo (2), Melgarejo |
| Resistencia | 0 | |||
| 17-abr-2023 | Doctor Juan | General Caballero | 3 | Costa, Sanguina, Arce |
| Leon Mallorquin | Sportivo Luqueño | 2 | Rojas, Castro | |
| 14º Fecha | ||||
| 22-abr-2023 | Encarnacion | Sportivo Trinidense | 1 | Barrios |
| Guaireña | 0 | |||
| 22-abr-2023 | Asuncion | Resistencia | 1 | Rodriguez |
| Sportivo Ameliano | 1 | Samudio | ||
| 23-abr-2023 | Asuncion | Tacuary | 0 | |
| Olimpia | 1 | Ortiz | ||
| 23-abr-2023 | Asuncion | Nacional | 2 | Cabrera, Alfaro |
| General Caballero | 0 | |||
| 24-abr-2023 | Luque | Sportivo Luqueño | 0 | |
| Libertad | 2 | Villalba, Ramirez | ||
| 24-abr-2023 | Asuncion | Guarani | 0 | |
| Cerro Porteño | 3 | Morales, Churin, Aquino (P) | ||
| 15º Fecha | ||||
| 27-abr-2023 | Doctor Juan | General Caballero | 1 | Baez |
| Leon Mallorquin | Tacuary | 0 | ||
| 27-abr-2023 | Asuncion | Olimpia | 1 | Ortiz |
| Sportivo Trinidense | 1 | Delvalle | ||
| 28-abr-2023 | Asuncion | Cerro Porteño | 2 | Rivas, Bobadilla |
| Guaireña | 0 | |||
| 28-abr-2023 | Asuncion | Guarani | 1 | Rivarola |
| Resistencia | 0 | |||
| 29-abr-2023 | Asuncion | Libertad | 2 | Gonzalez, Sanabria |
| Nacional | 1 | Ocampos | ||
| 1-may-2023 | Luque | Sportivo Ameliano | 2 | Sarquis, Vera |
| Sportivo Luqueño | 0 | |||
| 16º Fecha | ||||
| 5-may-2023 | Asuncion | Nacional | 1 | Fleitas |
| Sportivo Ameliano | 0 | |||
| 6-may-2023 | Luque | Sportivo Luqueño | 3 | Mendoza, Fernandez (2) |
| Guarani | 0 | |||
| 6-may-2023 | Encarnacion | Sportivo Tirnidense | 2 | Alvarez, Arce |
| General Caballero | 0 | |||
| 7-may-2023 | Asuncion | Resistencia | 1 | Da Silva |
| Cerro Porteño | 2 | Samudio (P), Ruan (A) | ||
| 7-may-2023 | Villarrica | Guaireña | 1 | Acosta |
| Olimpía | 0 | |||
| 8-may-2023 | Asuncion | Tacuary | 3 | Valdez (2), Rodriguez |
| Libertad | 0 | |||
| 17º Fecha | ||||
| 11-may-2023 | Doctor Juan | General Caballero | 3 | Gonzalez (2), Arce |
| Leon Mallorquin | Guaireña | 0 | ||
| 12-may-2023 | Luque | Sportivo Ameliano | 2 | Samudio, Doldan |
| Tacuary | 1 | Valdez | ||
| 12-may-2023 | Asuncion | Libertad | 2 | Sanabria, Bareiro |
| Sportivo Trinidense | 1 | Riveros | ||
| 13-may-2023 | Asuncion | Cerro Porteño | 2 | Aquino (P), Espinola |
| Olimpia | 2 | Fernandez, Quintana | ||
| 14-may-2023 | Asuncion | Guarani | 2 | Santander (P), Moreira |
| Nacional | 2 | Aguilar, Ocampos | ||
| 14-may-2023 | Asuncion | Resistencia | 1 | Villalba |
| Sportivo Liqueño | 1 | Perez (P) | ||
| 18º Fecha | ||||
| 16-may-2023 | Villarrica | Guaireña | 0 | |
| Libertad | 2 | Gomez, Villalba | ||
| 16-may-2023 | Asuncion | Olimpia | 1 | Bruera |
| General Caballero | 1 | Gonzalez | ||
| 17-may-2023 | Luque | Sportivo Liqueño | 1 | Castro (P) |
| Cerro Porteño | 1 | Espinola | ||
| 17-may-2023 | Asuncion | Tacuary | 1 | Martinez |
| Guarani | 3 | Fariña, Barcelo, Borja | ||
| 18-may-2023 | Encarnacion | Sportiva Trinidense | 2 | Alvarez, Mana |
| Sportivo Ameliano | 0 | |||
| 18-may-2023 | Asuncion | Nacional | 0 | |
| Resistencia | 0 | |||
| 19º Fecha | ||||
| 20-may-2023 | Asuncion | Cerro Porteño | 1 | Aquino (P) |
| General Caballero | 2 | Perez, Arce | ||
| 20-may-2023 | Asuncion | Libertad | 1 | Cardozo (P) |
| Olimpia | 0 | |||
| 22-may-2023 | Asuncion | Guarani | 0 | |
| Sportivo Trinidense | 2 | Delvalle (2) | ||
| 22-may-2023 | Asuncion | Resistencia | 1 | Villalba |
| Tacuary | 0 | |||
| 22-may-2023 | Luque | Sportivo Ameliano | 1 | Duarte |
| Guaireña | 1 | Nuñez | ||
| 22-may-2023 | Luque | Sportivo Luqueño | 0 | |
| Nacional | 1 | Martinez | ||
| 20º Fecha | ||||
| 27-may-2023 | Encarnacion | Sportivo Trinidense | 2 | Barrios, Riveros |
| Resistencia | 0 | |||
| 28-may-2023 | Doctor Juan | General Caballero | 0 | |
| Leon Mallorquin | Libertad | 2 | Riveros, Mendieta | |
| 28-may-2023 | Asuncion | Nacional | 2 | Alfaro (2, 1P) |
| Cerro Porteño | 1 | Samudio | ||
| 29-may-2023 | Villarrica | Guaireña | 2 | Gonzalez, Valdez |
| Guarani | 2 | Dorrego, Cespedes | ||
| 29-may-2023 | Asuncion | Olimpia | 1 | Paiva |
| Sportivo Ameliano | 3 | F. Vera, E. Vera (2, 1P) | ||
| 30-may-2023 | Asuncion | Tacuary | 3 | Ruiz (2), Valdez |
| Sportivo Luqueño | 1 | Medina | ||
| 21º Fecha | ||||
| 2-jun-2023 | Asuncion | Cerro Porteño | 2 | Morales (P), Galeano |
| Libertad | 0 | |||
| 2-jun-2023 | Asuncion | Guarani | 1 | Benitez |
| Olimpia | 2 | Fernandez, Paiva | ||
| 2-jun-2023 | Luque | Sportivo Luqueño | 2 | Rojas, Alegre |
| Sportivo Trinidense | 2 | Alvarez, Gimenez (P) | ||
| 3-jun-2023 | Luque | Sportivo Ameliano | 0 | |
| General Caballero | 1 | Romero | ||
| 3-jun-2023 | Asuncion | Nacional | 2 | Aguilar (P), Ocampos |
| Tacuary | 0 | |||
| 4-jun-2023 | Asuncion | Resistencia | 0 | |
| Guaireña | 2 | Alborno, Verdun | ||
| 22º Fecha | ||||
| 9-jun-2023 | Villarrica | Guaireña | 0 | |
| Sportivo Luqueño | 2 | Ferreira, Charpentier | ||
| 9-jun-2023 | Asuncion | Libertad | 1 | Lezcano |
| Sportivo Ameliano | 1 | Vera (P) | ||
| 10-jun-2023 | Doctor Juan | General Caballero | 0 | |
| Leon Mallorquin | Guarani | 0 | ||
| 10-jun-2023 | Encarnacion | Sportivo Trinidense | 2 | Delvalle, Riveros |
| Nacional | 1 | Ocampos | ||
| 11-jun-2023 | Asuncion | Tacuary | 2 | Edson Carius, Dominguez (P) |
| Cerro Porteño | 2 | Morales, Bobadilla | ||
| 11-jun-2023 | Asuncion | Olimpia | 4 | Quintana, Fernandez (2), Silva |
| Resistencia | 1 | Garcete (P) | ||